Affinity DataIC50: 0.0400nMAssay Description:Antagonist activity at human P2X7 receptor transfected in THP1 cells assessed as inhibition of benzoyl-ATP-induced changes in plasma membrane pore fo...More data for this Ligand-Target Pair
Affinity DataIC50: 0.0900nMAssay Description:Inhibition of HDAC (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 0.140nMAssay Description:Inhibition of Staphylococcus aureus DNA gyraseMore data for this Ligand-Target Pair
Ligand Info
Affinity DataIC50: 0.210nMAssay Description:Inhibition of Escherichia coli DNA gyraseMore data for this Ligand-Target Pair
Affinity DataIC50: 0.210nMAssay Description:Inhibition of Escherichia coli DNA gyraseMore data for this Ligand-Target Pair
Ligand Info
Affinity DataIC50: 0.210nMAssay Description:Inhibition of Escherichia coli DNA gyraseMore data for this Ligand-Target Pair
Ligand Info
Affinity DataIC50: 0.210nMAssay Description:Inhibition of Escherichia coli DNA gyraseMore data for this Ligand-Target Pair
Ligand Info
Affinity DataIC50: 0.210nMAssay Description:Inhibition of Escherichia coli DNA gyraseMore data for this Ligand-Target Pair
Ligand Info
Affinity DataIC50: 0.210nMAssay Description:Inhibition of Escherichia coli DNA gyraseMore data for this Ligand-Target Pair
Ligand Info
Affinity DataIC50: 0.216nMAssay Description:Inhibition of CDK2/cyclin E1 (unknown origin) incubated for 60 mins in presence of ATP by ADP-Glo luminescent Kinase AssayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.216nMAssay Description:Inhibition of CDK2/cyclin E1 (unknown origin) incubated for 60 mins in presence of ATP by ADP-Glo luminescent Kinase AssayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.260nMAssay Description:Antagonist activity at human P2X7 receptor transfected in THP1 cells assessed as inhibition of benzoyl-ATP-induced changes in plasma membrane pore fo...More data for this Ligand-Target Pair
Affinity DataIC50: 0.5nMAssay Description:Antagonist activity at human P2X7 receptor transfected in THP1 cells assessed as inhibition of benzoyl-ATP-induced changes in plasma membrane pore fo...More data for this Ligand-Target Pair
Affinity DataIC50: 0.650nMAssay Description:Inhibition of Staphylococcus aureus DNA gyrase supercoiling incubated for 30 mins in presence of ATP by ethidium bromide staining based analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 0.700nMAssay Description:Activity at Histamine H2 receptor using functional H2 receptor assay on guinea pig atriumMore data for this Ligand-Target Pair
Affinity DataIC50: 0.770nMAssay Description:Inhibition of Escherichia coli DNA gyraseMore data for this Ligand-Target Pair
Affinity DataIC50: 0.900nMAssay Description:Inhibition of PDE3 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 0.950nMAssay Description:Inhibition of Staphylococcus aureus DNA gyrase assessed as relaxation of pBR322 DNA by supercoiling assayMore data for this Ligand-Target Pair
Ligand Info
Affinity DataIC50: <1nMAssay Description:Inhibition of JAK (unknown origin)More data for this Ligand-Target Pair
Ligand Info
Affinity DataIC50: 1nMAssay Description:Inhibition of GST-tagged human CDK2/Cyclin A2 expressed in baculovirus infected Sf9 cells using 5-FAM-QSPKKG-CONH2 as substrate incubated for 60 mins...More data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Ability to displace [3H]glycine from strychnine-insensitive glycine receptorMore data for this Ligand-Target Pair
Affinity DataIC50: <1nMAssay Description:Inhibition of JAK (unknown origin)More data for this Ligand-Target Pair
Ligand Info
Affinity DataIC50: <1nMAssay Description:Inhibition of JAK (unknown origin)More data for this Ligand-Target Pair
Ligand Info
Affinity DataIC50: <1nMAssay Description:Inhibition of JAK (unknown origin)More data for this Ligand-Target Pair
Ligand Info
Affinity DataIC50: <1nMAssay Description:Inhibition of JAK (unknown origin)More data for this Ligand-Target Pair
Ligand Info
Affinity DataIC50: 1.20nMAssay Description:Inhibition of Staphylococcus aureus DNA gyrase supercoiling incubated for 30 mins in presence of ATP by ethidium bromide staining based analysisMore data for this Ligand-Target Pair
Ligand InfoPDB
Affinity DataIC50: 1.20nMAssay Description:Inhibition of BCR-ABL (unknown origin) expressed in mouse BaF3 cells assessed as cell growth inhibition incubated for 20 mins by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.40nMAssay Description:Inhibition of human PD-1/PD-L1 interactionMore data for this Ligand-Target Pair
Affinity DataIC50: 1.5nMAssay Description:Inhibition of HDAC (unknown origin)More data for this Ligand-Target Pair
Ligand Info
Affinity DataIC50: 1.5nMAssay Description:Inhibition of CDK2/cyclin E1 (unknown origin) incubated for 60 mins in presence of ATP by ADP-Glo luminescent Kinase AssayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.5nMAssay Description:Inhibition of CDK2/Cyclin E1 (unknown origin) assessed as inhibition of substrate peptide phosphorylation using eIF4E-binding protein 1 as peptide su...More data for this Ligand-Target Pair
Ligand Info
Affinity DataIC50: 1.70nMAssay Description:Inhibition of Escherichia coli DNA gyraseMore data for this Ligand-Target Pair
Ligand Info
Affinity DataIC50: 1.70nMAssay Description:Inhibition of Staphylococcus aureus DNA gyrase assessed as relaxation of pBR322 DNA by supercoiling assayMore data for this Ligand-Target Pair
Ligand Info
Affinity DataIC50: 1.70nMAssay Description:Inhibition of CDK2/cyclin E1 (unknown origin) incubated for 60 mins in presence of ATP by ADP-Glo luminescent Kinase AssayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.70nMAssay Description:Antagonist activity at human P2X7 receptor transfected in THP1 cells assessed as inhibition of benzoyl-ATP-induced changes in plasma membrane pore fo...More data for this Ligand-Target Pair
Affinity DataIC50: 1.70nMAssay Description:Inhibition of Escherichia coli DNA gyraseMore data for this Ligand-Target Pair
Affinity DataIC50: 1.80nMAssay Description:Inhibitory activity against Dihydrofolate reductase in Neisseria gonorrhoeaeMore data for this Ligand-Target Pair
Affinity DataIC50: 1.80nMAssay Description:Inhibition of Hepatitis C virus genotype 3a NS3/NS4A proteaseMore data for this Ligand-Target Pair
Affinity DataIC50: 1.80nMAssay Description:Dissociation constant against VEGF (vascular endothelial growth factor) was determined.More data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Inhibition of Platelet-derived growth factor receptor in P19 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Blocking activity against Beta-1 adrenergic receptor in spontaneously beating guinea pig atrial preparationsMore data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Antagonist activity at M3 receptor in Dunkin-Hartley guinea pig trachea assessed as inhibition of methacholine-induced airway smooth muscle contracti...More data for this Ligand-Target Pair
TargetPlatelet-derived growth factor receptor alpha/beta(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development
Curated by ChEMBL
Johnson & Johnson Pharmaceutical Research & Development
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Inhibition of Protein kinase C beta 1More data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Inhibition of Bcr-Abl T315I mutant (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 2.30nMAssay Description:Inhibition of Staphylococcus aureus DNA gyrase assessed as relaxation of pBR322 DNA by supercoiling assayMore data for this Ligand-Target Pair
Ligand Info
Affinity DataIC50: 2.30nMAssay Description:Inhibition of human PD-1/PD-L1 interactionMore data for this Ligand-Target Pair
Affinity DataIC50: 2.40nMAssay Description:Inhibition of C-terminal His6 tagged human full length CDK1/N-terminal GST-tagged human full length Cyclin B expressed in baculovirus infected Sf21 c...More data for this Ligand-Target Pair
Affinity DataIC50: 2.5nMAssay Description:In vitro antagonism of the 5-HT-3 receptor determined by inhibition of 5-HT-induced depolarization of the isolated rat vagus nerve.More data for this Ligand-Target Pair
Affinity DataIC50: 2.70nMAssay Description:The compound was evaluated for its relative binding affinity against mutant N131A scytalone dehydratase; Relative KiMore data for this Ligand-Target Pair
Affinity DataIC50: 2.90nMAssay Description:Inhibition of Staphylococcus aureus DNA gyrase assessed as relaxation of pBR322 DNA by supercoiling assayMore data for this Ligand-Target Pair